Tolerance to anorexigenic effect

Formation and ways to overcome tolerance to anorexigenic effect of Phentermine

There is a high risk of developing tolerance to anorexigenic effect in long-term use of Phentermine tablets. Tolerance is a state of the body in which therapeutic effect of Phentermine decreases. In other words, the patient ceases to lose weight using this anorectic.

There are several reasons for formation of tolerance to Phentermine anorexigenic effect:

Previous experience of using psychostimulant drugs
Decreased sensitivity of the brain receptors to the drug action
Non-compliance with dosage and recommendations for the anorectic use
Irrational use of the medication ("off-label use")
Malabsorption of the drug because of stomach or liver problems.

Formation of tolerance to Phentermine anorexigenic effect occurs in several stages:

1. The patient begins obesity treatment with the minimal dose of Phentermine – 8 mg three times per day. Over time, he observes that regular intake of the medication no longer contributes to appetite suppression and weight loss.

2. The attending physician recommends the patient to increase the anorectic dose up to 30 mg once daily. Subsequently, the higher dose of the drug becomes ineffective for anorexigenic effect and weight loss. The patient needs a further increase in the anorectic dose.

3. After all, Phentermine stops working and becomes useless for weight loss when using a dose of 40 mg. Since 40 mg is the maximum tolerated dose of this anorectic, its increase becomes potentially dangerous to health.

The first signs of tolerance to Phentermine anorexigenic effect (insomnia, increased appetite) may appear within 2-4 weeks after beginning of obesity treatment.

In daily intake of Phentermine, the anorexic effect gradually weakens, and then completely disappears.

If not to stop taking Phentermine, then tolerance to its anorexigenic effect can develop into the drug dependence over time. That is, the patient will experience a need for use this drug without clinical justification.

Some patients cannot achieve the anorexigenic effect even after the first dose of Phentermine. The presence of tolerance to the anorexigenic effect of Phentermine can be caused by genetic characteristics of the body.

What to do if Phentermine is no longer effective in weight reduction:

  • Use another medication to reduce weight
  • Use non-drug methods of obesity treatment (diet therapy, physical exercise)
  • Consult a healthcare professional involved in drug dependence treatment.
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