2-4-Dinitrophenol (DNP) was one of the first antiobesity therapy used in the 1930s. Its effect was first noticed among factory workers who were exposed to this and lost weight. It was shown to cause weight loss by uncoupling oxidative phosphorylation, leading to a heightened metabolic rate and increased fat metabolism.
How does DNP make you lose weight?
DNP can cause a significant increase in the basal metabolic rate [7, 8]. This leads to weight loss by burning more fat and carbohydrates , and weight loss of up to 1.5 kg per week is reported without significant side effects.
Why is DNP an effective weight loss drug?
DNP (2,4-Dinitrophenol) has a variety of industrial uses, including as a photographic chemical, a fertilizer and in the manufacturing of dyes and explosives. It causes weight loss by burning fat and carbohydrates, in turn causing energy to be converted into heat.
Why is DNP dangerous?
Why is DNP so dangerous? One of the risks of DNP is that it accelerates the metabolism to a dangerously fast level. Speeding up the metabolism may help burn off fat, but it can also trigger a number of potentially dangerous side effects, such as: fever.
How does DNP cause hyperthermia?
DNP causes a hyper-metabolic state by uncoupling oxidative phosphorylation. Energy is released in the mitochondria as heat. The body attempts to compensate by gluconeogenesis, glycolysis, and lipolysis.
Does DNP stop ATP production?
DNP transports protons across the mitochondrial inner membrane, altering the proton gradient and inhibiting ATP production via OXPHOS (Lou et al., 2007).
What does DNP stand for?
Many wonder, “What does DNP stand for?” DNP is the acronym for Doctor of Nursing Practice. The DNP is an advanced nursing degree that allows nurses who have strong backgrounds in clinical practice to progress within the health care field.
Is DNP liver toxic?
Symptoms of acute toxicity from DNP include hyperthermia, a rapid pulse, sweating, an increased respiratory rate and cardiac arrest. Profuse, yellow-tinted perspiration may be observed in DNP poisoning. Damage to the liver, kidneys and the nervous system may also occur.
Can DNP be taken safely?
This drug is highly dangerous and should not be being used for weight loss. Sellers are preying on the most vulnerable individuals by continuing to supply it despite countless warnings and bans against ingesting this product. There is no such thing as a safe dose of DNP, don’t take the gamble.
Is DNP muscle sparing?
“If you know what you’re doing and are reasonable about what to expect,” she writes, then “DNP is an extremely powerful fat loss drug — its muscle sparing properties are unlike anything else”.
What is DNP legally used for today?
DNP can be legally sold as a fertilizer in many countries and many retailers use this as a loophole to sell it as a weight-loss drug.
What is DNP metabolism?
Dinitrophenol (DNP) is an uncoupler, or has the ability to separate the flow of electrons and the pumping of H+ ions for ATP synthesis. This means that the energy from electron transfer cannot be used for ATP synthesis. Fifty years ago, DNP was given as a drug to help patients lose weight.
Is DNP legal in UK?
2,4-dinitrophenol (DNP) is a highly toxic industrial chemical. It has been illegally sold as a diet pill for weight loss. … It is a crime to sell DNP for human consumption in the UK. Those selling DNP can find themselves prosecuted under the Food Safety Act 1990.
Why does DNP increase respiration?
Abstract. Mitochondrial uncouplers, such as 2,4 dinitrophenol (DNP), increase the cellular respiration by decreasing mitochondrial membrane potential (delta psi).
How does DNP affect glycolysis?
increase in the absence of DNP is simply due to an increase in glycolysis as a result of the removal of oxygen. … DNP is supposed to affect only oxidative phosphorylation, while substrate phos- phorylation, which occurs during glycolysis, is not affected.
Why does DNP increased oxygen consumption?
The increase of oxygen consumption after the addition of 2,4-dinitrophenol (DNP) is explained as being a result of dissociation between oxidative and phosphorylative processes. Similarly, thyroxine accelerates oxidation by uncoupling an oxidative phosphorylation.