Qsymia potential risks

The results of the American clinical studies have proved that benefit and effectiveness of Qsymia greatly exceed any potential risks.

However, the European Medicines Agency (EMA) rejected a request of Vivus, the manufacturer of Qsymia, for authorization to supply these diet pills to the European market because of cardiovascular risks.

Before using Qsymia, it is recommended to evaluate appropriateness of obesity pharmacotherapy, or to establish an adequate dosage schedule.

Dose adjustment helps significantly reduce a potential risk of Qsymia adverse reactions in elderly patients.

  • There is a potential risk of cognitive disorders, such as memory disorder, impairment of attention and / or coordination at the beginning of Qsymia use;
  • When increasing Qsymia dose, risk of its side effects also increases, including insomnia, dry mouth or constipation;
  • Qsymia has a high potential for myopia, and is contraindicated in patients with a history or presence of acute closed-angle glaucoma.

When using Qsymia, risk of arrhythmia or elevated blood pressure increases in patients with cardiovascular diseases. Therefore, obese patients with cardiac dysfunctions are advised to take precautions during obesity pharmacotherapy.

Qsymia has a potential teratogenic risk. During a course of these diet pills, women should use barrier methods of birth control and / or oral contraceptives. If a woman becomes pregnant during Qsymia course, obesity pharmacotherapy should be stopped.

Qsymia

Qsymia also has a potential risk of psychiatric disorders, such as suicidal thoughts or depression. These Qsymia undesirable events quickly pass after completion of obesity pharmacotherapy course.

Because of a potential risk of drug interaction, Qsymia is contraindicated together with MAO inhibitors, including:

  • Rasagiline, also known as Azilect
  • Tranylcypromine, popular as Parnate
  • Selegiline, also known as Eldepryl, Emsam or Zelapar
  • Isocarboxazid, sold under the name Marplan
  • Phenelzine, produced under the brand Nardil.

To reduce a potential risk of hypoglycemia, obese diabetics may need a reduction of Metformin or Insulin dose during Qsymia course.

Phentermine, one of the Qsymia components, has a dependence potential. However, this drug for obesity treatment includes minimal doses of active ingredients. Therefore, Qsymia has a minimal risk of dependence.

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