What can happen when you mix Qsymia with alcohol?
When ingested all alcoholic drinks enter into pharmacokinetic and pharmacodynamic interactions with Qsymia. These interactions do not only reduce effectiveness of anti-obesity therapy, but also increase the likelihood of side effects. Therefore, all endocrinologists are unanimous in their opinion about absolute incompatibility of Qsymia with alcohol.
Depending on the patient’s individual characteristics, alcohol (or ethanol) can slow or vice versa enhance Qsymia metabolism. For example, simultaneous use of Qsymia with alcohol leads to decrease in anorexigenic effect in people with chronic alcohol dependence.
What does happen in the body when Qsymia interacts with alcohol?
- water-electrolyte imbalance;
- stimulation of catecholamines release: noradrenaline, serotonin and others;
- enhancement of the central effects of the drug: increased heart rate and respiratory rate, euphoria and others;
- increase in permeability of the blood-brain barrier, that is, an increase in stimulating effect of the anorectic.
When using Qsymia with alcohol, water-electrolyte imbalance is accompanied by such symptoms as dryness of the skin and of mucous membranes, edema, impaired renal function, lower blood pressure, and others.
The body dehydration occurs due to the fact that Qsymia and Ethanol contribute to violation of water absorption in the upper sections of the gastrointestinal tract. Severe electrolyte imbalance, caused by interaction of alcohol and this anorectic contributes to decrease in the volume of circulating blood that in turn causes decrease in blood pressure.
Alcohol stimulates activation of the adrenal glands and release of neurotransmitters, noradrenaline and serotonin. Thus, alcohol potentiates therapeutic effect of Qsymia that is also aimed at increase of catecholamines concentration in the brain.
In addition, catecholamines released by the adrenal glands increase need of tissues for glucose. Therefore, energy deficit arising from interaction of Qsymia with alcohol leads to the patient’s nervous and physical exhaustion.
As a result of increasing the blood-brain barrier permeability, volume of Qsymia distribution increases. Intensity of the central effects of this anorectic increases: the depressing effect on the respiratory center and tachycardia.
Thus, use of Qsymia with alcohol has a potentiating effect on the central nervous system. After taking this anorectic and alcohol, the person can fall into a deep sleep and subsequently not remember anything that happened to him.
Alcohol can inhibit enzymes that are involved in the drug metabolism. Since this drug is a psychostimulant, interaction of Qsymia with alcohol contributes to sedative effect or vice versa – hyperstimulation of the body occurs.
Under alcohol influence, formation of metabolites Phentermine and Topiramate, the active ingredients of Qsymia, is slowed down.
Violation of the drug pharmacokinetics leads to:
- slowing of the drug excretion from the body
- increased likelihood of side effects
- increase in concentration of drugs in the blood plasma
Ethanol does not only provide central effect on the body, alcohol is a powerful inducer of hepatic metabolism. Since basic metabolic process of Qsymia occurs in the liver, combination of Qsymia with alcohol significantly increases risk of hepatotoxicity.
Thus, the likelihood of severe intoxication and serious side effects increases because of interaction of Qsymia with alcohol. Only after finishing anti-obesity therapy using Qsymia, the patient can start drinking alcohol.