Mysimba Contraindications

Like other drugs for the treatment of overweight and obesity, Mysimba has certain contraindications to its use.

Contraindications to the use of Mysimba can be divided into two groups:

  • Relative contraindications.
  • Absolute (permanent) contraindications.

Relative Mysimba contraindications is a condition of the patient, when, for a certain reason, the use of the drug is possible, yet only under a constant doctor’s supervision.

After a careful assessment of the risk and benefit ratio, the specialist decides on the admissibility of the drug use.

Relative contraindications to Mysimba use are:

  • Controlled hypertension.
  • Mild to moderate renal and hepatic impairment.
  • Adolescence (under 18 years of age) and advanced age (over 65 years).
  • Co-administration of Mysimba with antidepressants, corticosteroids, antibiotics, and antihistamines.

Despite the contraindications, Mysimba may sometimes be prescribed to patients under the age of 18. Particular care requires the use of the drug in elderly patients with moderate hepatic or renal insufficiency.

Controlled hypertension is also not an absolute contraindication to Mysimba use. Caution should be given when centrally acting antihypertensives are taken concurrently with Mysimba.

In cases of relative contraindications, only the attending physician can take the decision on the advisability of Mysimba use.

Both Mysimba and alcohol affect the human central nervous system (CNS). Despite the fact that no clinically significant interaction between Mysimba and alcohol was registered during the trials, the consumption of alcohol-containing drinks should be minimized.

The consumption of alcohol during the use of Mysimba may be the absolute contraindication in patients that suffer from hypertension.

Absolute contraindications are pathological conditions of a person, in which treatment with Mysimba is strictly not recommended because of possible life-threatening situations.

Absolute contraindications to Mysimba use are:

  • CNS tumors.
  • Seizure disorders.
  • Uncontrolled hypertension.
  • Severe hepatic and renal impairment.
  • Eating disorders: bulimia or anorexia nervosa.
  • Concomitant administration with MAO inhibitors or opiate agonists.

Another absolute contraindication is the patient’s hypersensitivity to the active and inactive ingredients of Mysimba. It is almost impossible to predict in advance whether a person is allergic to Naltrexone or Bupropion.

Therefore, in early treatment with Mysimba, patients are recommended to carefully monitor the response of their body to the drug. If a person experiences face and lips swelling, chest pain, itching, breathing problems, rash, he should discontinue the drug.

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