Gentamicin is not metabolized in the body but is excreted unchanged in microbiologically active form predominantly via the kidneys. In patients with normal renal function the elimination halflife is about 2 to 3 hours. In neonates elimination rate is reduced due to immature renal function.
Is gentamicin excreted through the kidneys?
Gentamicin is excreted unmodified by the kidneys, and for this reason, follows “first order kinetics”.
How is gentamicin absorbed?
Absorption & Distribution
Gentamicin is rapidly absorbed after IM injection and peak serum levels are usually achieved within 30 to 90 minutes and are measurable for 6-8 hours. Following parenteral administration, gentamicin can be detected in tissues and body fluids.
Is gentamicin an acid or a base?
Gentamicin is a very strong basic compound (based on its pKa). In humans, gentamicin is involved in gentamicin action pathway.
What are the pharmacokinetics of gentamicin?
Gentamicin is excreted unmodified, by the kidneys and so follows “first order kinetics”. i.e. drug is cleared from blood at a rate proportional to it’s concentration. After a bolus dose, level in the blood decays exponentially. Kidneys continuously removing a constant fraction of gentamicin in the blood.
How long does gentamicin stay in your system?
Gentamicin is not metabolized in the body but is excreted unchanged in microbiologically active form predominantly via the kidneys. In patients with normal renal function the elimination halflife is about 2 to 3 hours.
What are the side effects of gentamicin?
Gentamicin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- decreased appetite.
- pain at the injection site.
- joint pain.
Is gentamicin a strong antibiotic?
Gentamicin is a broad spectrum aminoglycoside antibiotic that is most effective against aerobic gram-negative rods. Gentamicin is also used in combination with other antibiotics to treat infections caused by gram positive organisms such as Staphylococcus aureus and certain species of streptococci.
Why is gentamicin not absorbed orally?
Aminoglycosides such as gentamicin cannot be administered orally for treatment of systemic infection because they are not absorbed from the intact gastrointestinal tract . Analysis of peak and trough concentrations reveal significant interpatient variability within and between studies.
What bacteria does gentamicin target?
Gentamicin is an aminoglycoside antibiotic. It exhibits bactericidal activity against aerobic gram-negative bacteria makes gentamicin a good option to treat several common infections.
What family is gentamicin in?
This medication is used to prevent or treat a wide variety of bacterial infections. Gentamicin belongs to a class of drugs known as aminoglycoside antibiotics. It works by stopping the growth of bacteria.
What class of antibiotic is gentamicin?
Gentamicin injection is used to treat serious bacterial infections in many different parts of the body. Gentamicin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth.
What is gentamicin sulfate used for?
This medication is used to treat minor skin infections (such as impetigo, folliculitis) or minor infections related to some skin conditions (such as eczema, psoriasis, minor burns/cuts/wounds). Gentamicin works by stopping the growth of certain bacteria.
What does gentamicin do to bacteria?
Gentamicin is the most commonly used aminoglycoside antibiotic and is indicated for moderate-to-severe bacterial infections caused by sensitive agents, primarily gram negative bacteria. Like other aminoglycosides, gentamicin is thought to act by binding to bacterial ribosomes and inhibiting protein synthesis.
What is the indication of gentamicin?
Gentamicin (gentamicin injection pediatric) Injection is indicated in the treatment of serious infections caused by susceptible strains of the following microorganisms: Pseudomonas aeruginosa, Proteus species (indole-positive and indole-negative), Escherichia coli, Klebsiella-Enterobacter-Serratia species, Citrobacter …
Is gentamicin a penicillin?
Tetracyclines (e.g. doxycycline), quinolones (e.g. ciprofloxacin), macrolides (e.g. clarithromycin), aminoglycosides (e.g. gentamicin) and glycopeptides (e.g. vancomycin) are all unrelated to penicillins and are safe to use in the penicillin allergic patient.