History of Phentermine (when it became available for sale) goes back as many as nearly 55+ years. First approved by the FDA as an appetite suppressant in 1959 and formulated as Phentermine Hydrochloride, it was introduced to the market of prescription diet medications in the early 1970s. Since that time it has managed to get a share equal to nearly half of all the prescriptions written out.
Phentermine since 1970s
Since 1970s Phentermine has always been ”tried” in a combination with other compounds. The first such combination was introduced as Fen-Phen (Fenfluramine-Phentermine) diet drug cocktail in the early 1990s. The prescription and market presence of this medication, however, appeared to be brief: in 1997 the drug cocktail was taken off the market on the FDA’s initiative. Another similar combination, Dexfen-Phen (Dexfenfluramine-Phentermine), appeared to have a similar ”problem”. They both seemed to cause heart valve disease.
Attempts to combine Phentermine with other compounds used for obesity haven’t stopped though. Since 2012 (when it was first approved by the FDA), Qsymia (formerly Qnexa) has become available as a treatment option for obesity. Here appetite suppressing properties of Phentermine are enhanced by Topiramate, an anticonvulsant drug.