The secret of high efficiency of Duromine pills is in its manufacture technology.
Duromine is a medicine for obesity treatment, fairly considered to be on the top of the list of most prescribed anti-obesity medicines over the last decade. A key advantage of Duromine is that a single dose of the medicine is sufficient to control appetite from the morning till the evening.
Due to its long anorectic action, Duromine is ideal for once-daily dosing.
At the same time, Duromine is formulated so that being very strong, not to be toxic. Therefore, it is a long and powerful anorectic action does not cause additional risks for development of unwanted side effects.
Ion-exchange resin is contained in the composition of Duromine to persistently maintain the blood concentration of the active ingredient Phentermine at therapeutically effective levels. An ion-exchange resin slows down the release of the active ingredient Phentermine, and thus increases its anorectic effect duration.
An ion-exchange resin complex is stable at interaction with food and water, and releases Phentermine only interacting with the gastric juice. Therefore, the amount of food and water consumed does not affect the speed of Phentermine release.
Interacting with the gastric acid, an ion-exchange resin releases Phentermine gradually, at the same speed. Therefore, an anorectic action of Phentermine (Duromine) remains at a high level for a long time, sufficient to control appetite.
An ion-exchange resin is a polymer compound, not absorbed by the body. Therefore, it is not toxic and completely excreted from the body unchanged.
Because of an ion-exchange resin that releases Phentermine slowly and gradually, Duromine pills are characterized by several competitive advantages over other Phentermine-containing drugs.
First, a long-acting anorectic effect reduces frequency of Duromine dose intakes up to once a day. Once-daily administration makes obesity treatment more convenient, and significantly reduces a chance to miss scheduled doses of Duromine.
Second, because of the low release of Phentermine:
- risk of acute overdose is reduced
- abuse potential is reduced
- intensity of side effects is decreased
Duromine has several serious disadvantages, the main is that Duromine has many contraindications.
Duromine pills should not be prescribed to obese men and women with:
- Cardiovascular risks or previously diagnosed severe cardiovascular/cerebro-vascular disease.
- Have had or have mental or psycho-emotional disorders.
- History of allergic reactions to sympathomimetic or medicines from the group of amphetamines / amphetamine derivatives.
- Diagnosed hyperthyroidism (overactive thyroid gland) or glaucoma.
Also Duromine should not be indicated to children and adolescents under 12 years of age, and to adults who have ever:
- alcohol or drug abusing;
- suffered from alcohol or drug dependence.
Teens over 12 years of age and adult men and women with no contraindications to Duromine can use these diet pills for continuous anti-obesity therapy up to three months.
Once three-month therapy is ended, ratio of benefits and risks of Duromine should be evaluated, and further obesity treatment to be decided to continue or terminate.
The most common cause of Duromine withdrawal after three-month treatment course is reduced effectiveness of the anti-obesity medicine.
Efficiency can be reduced because prolonged use of Duromine pills may develop in patients tolerance to its anorectic effect.
Any signs of tolerance to Duromine disappear within few weeks or months after the three-month anti-obesity therapy. If diagnostic tests confirm no tolerance to Duromine effects, application of these diet pills can be resumed.
Besides tolerance to an anorectic action, Duromine pills may cause other adverse events, including cardiovascular, psychiatric, and gastrointestinal side effects.
If side effects are mild to moderate, Duromine dosage should not be changed or stopped. If undesired side effects are adverse or cause serious risks for general health, the patient can be recommended to:
- stop using Duromine for weight loss, or
- reduce the total daily dose / frequency of Duromine application
To fight against obesity, diet pills Duromine containing different doses of anorectic agent Phentermine can be prescribed. Each Duromine pill may contain:
- 15 mg of Phentermine
- 30 mg of Phentermine
- 40 mg of Phentermine
The minimum effective daily dosage of Duromine makes 15mg per day. The maximum safe dose of Duromine is 40mg per day.
Capsules of 40mg Duromine are sold in Australia and Hong Kong, but not available in New Zealand, South Africa, and at other regional pharmaceutical markets. Therefore, in some countries, Duromine 40mg pills are not available.
It should be noted that in different countries, Duromine is indicated to different groups of patients. For example:
- In New Zealand Duromine is approved for obesity treatment in patients with a body mass index (BMI) of 30 or higher.
- In Australia, Hong Kong, and South Africa Duromine is indicated for weight loss to patients with BMI equal to 25 or higher.
In addition to the said countries, in 2016, Duromine pills are very popular in Malaysia, Thailand, the Philippines, El Salvador, Singapore, United Kingdom, Costa Rica.
Duromine is exclusively supplied to all these countries by Valeant, a multinational pharmaceutical company, and its subsidiaries. Valeant is the owner of Duromine trademark and owns exclusive rights to supply Duromine pills to Asia Pacific and Africa countries.
Valeant is only one of several companies associated with a history of Duromine. Duromine brand was registered in 1960, and in different periods various pharmaceutical companies were related to this brand name.
3M Health Care (in the UK) and Inova (in Australia) were mentioned as the first right holders, manufacturers, and suppliers of Duromine at the international market.
iNova has been a subsidiary of 3M Pharmaceuticals for many years. But in 2006, 3M Pharmaceuticals sold its subsidiary iNova, including all patent rights to Duromine, to Ironbridge and its co-investor Archer Capital.
From 2006 to 2011, Archer Capital and Ironbridge ran iNova and were directly involved into Duromine commercialization in the international market.
In 2011, Archer Capital and Ironbridge decided to sell Inova and all rights to Duromine brand to Valeant company.
From 2011 till now, Valeant has been an exclusive owner of Duromine brand. However different pharmaceutical companies are still indicated as manufacturers, suppliers, distributors, and marketing authorization holders for Duromine.
- The manufacturers of active ingredient Phentermine (contained in Duromine) are US companies Siegfried and Rhodia ChiRex.
- The manufacturers of dosage form of Duromine are Douglas Pharmaceuticals and Valeant Pharmaceuticals.
- The marketing authorization holder for Duromine in NZ is Bausch & Lomb (from 2014 joined Valeant).
- The marketing authorization holder for Duromine in South Africa, Australia, Hong Kong, Malaysia is iNova Pharmaceuticals.
In addition to Duromine pills, other Phentermine-containing anti-obesity drugs are available in some countries. For example, in Thailand and Singapore, Phentermine-containing pills Panbesy can be indicated instead of Duromine, and in the UK, and the Philippines – diet pills Ionamin.
Despite that Duromine pills are sold in a competitive environment, its price is annually growing in some countries. The most dynamic increase of Duromine cost is observed in South Africa.
At the end of 2015, the cost of one package* of 30 mg pill Duromine in South Africa amounted to about 280 ZAR**, and in just half a year increased by over 4 percentage points.
- *30 diet pills
- ** South African Rand
In mid-2016, one package Duromine 30mg cost 292 ZAR in South Africa. Taking into account exchange rate fluctuations and inflation, in the second half of 2016, the increase in Duromine cost is expected to remain in South Africa.
Duromine is well-known for Phentermine as its active ingredient that serves as a reliable appetite suppressant and weight loss aid. The medication works affecting the central nervous system, producing the desirable effect. The active component of the drug has a similar to antihistamine action and is potent to increase the level of energy.
Even though the medication is powerful and produces a drastic effect on diverse body functions, bare drug is not enough for a desirable result. An effective and fast treatment course should also include regular exercising and low-calorie diet.
Recommendations for Use, Side Effects
Despite Duromine is a prescription drug, there is a great number of online pharmacies offering the treatment over-the-counter. However, even purchasing the medication from trustworthy and reliable online drugstores, it is inevitable to receive doctor’s recommendations.
Consult your healthcare provider primarily to the treatment intake to ensure the medicine is safe and effective in your case, your general health condition suits the treatment and you do not meet any contraindications.
Inform your healthcare specialist about all the experienced and current health conditions and medications taken. Take Duromine right as prescribed by the doctor. Do not increase or decrease the recommended dose to avoid possible withdrawal reactions.
If you have missed a dose, take it as soon as possible, but omit it if the next scheduled one is soon to come.
Do not double the dose, as it can cause severe side effects. Among the most common Duromine downsides are euphoria, restlessness, fatigue, impotence, headaches, difficulty breathing, dry mouth, problems sleeping and others.
Seek medical advice if you have noticed any abnormalities or complications.